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↑ Clinical trial number NCT00638690 for "Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy" at ClinicalTrials.gov
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↑ Clinical trial number NCT00887198 for "Abiraterone Acetate in Asymptomatic or Mildly Symptomatic Patients With Metastatic Castration-Resistant Prostate Cancer" at ClinicalTrials.gov
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1 2 3 Small EJ (tháng 11 năm 2014). “Can targeting the androgen receptor in localized prostate cancer provide insights into why men with metastatic castration-resistant prostate cancer die?”. Journal of Clinical Oncology 32 (33): 3689–91. PMID25311216. doi:10.1200/JCO.2014.57.8534. Abiraterone acetate is a prodrug for abiraterone, a CYP17 inhibitor, which has the capacity to lower serum testosterone levels to less than 1 ng/dL (compared with levels closer to 20 ng/dL that are achieved with conventional ADT).19 [...] Relative to LHRHa alone, the addition of abiraterone resulted in an 85% decline in dihydrotestosterone (DHT) levels, a 97% to 98% decline in dehydroepiandrosterone (DHEA) levels, and a 77% to 78% decline in androstenedione levels.
↑ Yin L, Hu Q (tháng 1 năm 2014). “CYP17 inhibitors--abiraterone, C17,20-lyase inhibitors and multi-targeting agents”. Nature Reviews. Urology 11 (1): 32–42. PMID24276076. doi:10.1038/nrurol.2013.274.
↑ Malikova J, Brixius-Anderko S, Udhane SS, Parween S, Dick B, Bernhardt R, Pandey AV (tháng 11 năm 2017). “CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2”. The Journal of Steroid Biochemistry and Molecular Biology 174: 192–200. PMID28893623. doi:10.1016/j.jsbmb.2017.09.007.
↑ Udhane SS, Dick B, Hu Q, Hartmann RW, Pandey AV (tháng 9 năm 2016). “Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis”. Biochemical and Biophysical Research Communications 477 (4): 1005–1010. PMID27395338. doi:10.1016/j.bbrc.2016.07.019.
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↑ Yip CK, Bansal S, Wong SY, Lau AJ (tháng 4 năm 2018). “Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1”. Drug Metabolism and Disposition 46 (4): 470–482. PMID29436390. doi:10.1124/dmd.117.078980.
